- Social and behavioral prevention and treatment
- cancer detection, treatment and biology
- Cardiovascular and Cerebrovascular Disease
- Environmental Exposure and Toxicology
- Neuroscience of Nicotine Addiction and Treatment
- Oral Diseases and Dental Health
- Pulmonary Biology and Lung Diseases
- State and Local Tobacco Control Policy Research
- Other tobacco-related health effects
Pulmonary Biology and Lung Diseases
Support innovative, timely and high impact research addressing basic, translational or clinical aspects of tobacco-related pulmonary biology and lung diseases. TRDRP will support studies on lung diseases that the Report of the Surgeon General has identified as being caused by tobacco-related products. TRDRP will also support projects in which tobacco-related products or their constituents are integral to the proposed study. Research that can inform FDA regulations on new and emerging tobacco products is of particular interest.
Examples of relevant research topics:
- Molecular changes in various lung cell culture models or in animals or humans exposed to e-cigarette aerosol indicating the role of nicotine, flavorants or non-menthol synthetic cooling agents.
- Cellular interactions or molecular pathways that drive the inflammatory response in the lungs of tobacco users.
- The mechanisms (molecular, genetic, social) that drive differences in COPD susceptibility and progression in current and former commercial tobacco users.
- The role of combusted tobacco smoke or new and emerging tobacco products in the development and exacerbation of asthma, emphysema, COPD, or idiopathic pulmonary fibrosis.
- Impact of tobacco product use on the general lung health of youth or individuals in other tobacco priority populations.