- Social and behavioral prevention and treatment
- Cancer detection, treatment, and biology
- Cardiovascular and cerebrovascular diseases
- Environmental Exposure and Toxicology
- Neuroscience of Nicotine Addiction and Treatment
- Oral diseases and dental health
- Pulmonary biology and lung diseases
- State and Local Tobacco Control Policy Research
- Other tobacco-related health effects
Neuroscience of nicotine addiction and treatment
Advance innovative research that addresses the biology of nicotine addiction and treatment, with a goal of understanding and reducing tobacco use in populations that consistently have the highest smoking rates.
TRDRP supports innovative research that addresses the biology of nicotine addiction and treatment, with a goal of understanding and reducing commercial tobacco product use in populations that consistently have the highest smoking rates.
Examples of relevant research topics:
- Identify potential genetic, molecular, cellular, neuroimaging, cognitive, behavioral and/or developmental effects of nicotine on the brain.
- Studies of the potential for age-related differences in sensitivity and progression toward nicotine addiction and/or nicotine withdrawal.
- Development of therapeutic strategies for nicotine overdose, and preventative/therapeutic strategies for nicotine-addiction across the lifespan.
- Discern the health effects of flavorants , or tobacco products containing non-menthol synthetic cooling agents (e.g., WS-3 and WS-23).
- Understand the impact of vape product design and constituents of vape aerosol (including non-menthol cooling agents) on product preference, use and propensity toward nicotine addiction or cessation.
- Determine the potential impact of combined nicotine and cannabinoid use in nicotine addiction. on specific priority populations.
- Studies of brain connectivity and interaction between neural pathways utilized by different agonists (e.g., glutamatergic, cholinergic, dopaminergic, etc.) in nicotine addiction and withdrawal.