- Social and behavioral prevention and treatment
- cancer detection, treatment and biology
- Cardiovascular and Cerebrovascular Disease
- Environmental Exposure and Toxicology
- Neuroscience of Nicotine Addiction and Treatment
- Oral Diseases and Dental Health
- Pulmonary Biology and Lung Diseases
- State and Local Tobacco Control Policy Research
- Other tobacco-related health effects
Cancer Detection, treatment and biology
TRDRP will support research into the causes, early detection, and effective treatment, care, prevention, and potential cures of cancers that the Report of the Surgeon General has identified as being caused by tobacco products. TRDRP will also support projects in which tobacco products or their constituents are integral to the proposed study.
Example Research Topics:
- Clinical and/or pre-clinical studies on the carcinogenic potential of new tobacco products.
- Implementation strategies aimed at improving evidence-based tobacco treatment in diverse cancer care settings that evaluate cotinine and other tobacco biomarkers in priority populations.
- Mechanistic insights informing prevention strategies in patients who engage in co-use of cannabis and tobacco during cancer treatment.
- The impact of menthol synthetic cooling agents (such as WS-3 and WS-23) on cellular processes such as proliferation, cell cycle checkpoint mechanisms, and senescence.
- The development of therapeutic strategies for small cell lung cancer (SCLC) with assessments of therapeutic efficacy in smokers and non-smokers. Note: Lung cancer studies should focus on disease types that are strongly correlated with tobacco product use (e.g., SCLC).