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Pulmonary Biology and Lung Diseases

TRDRP supports innovative, timely and high impact research that addresses basic, translational, or clinical aspects of lung diseases. Research into the mechanisms, diagnosis, prevention, and treatment of lung  diseases resulting from the use of commercial tobacco products, with a focus on disproportionately affected groups, is of critical importance to reducing the negative impact of tobacco product use.

Examples of relevant research topics:  

  • Molecular changes in various lung cell culture models or in animals or humans exposed to e-cigarette aerosol indicating the role of nicotine, flavorants or non-menthol synthetic cooling agents.
  • Cellular interactions or molecular pathways that drive the inflammatory response in the lungs of tobacco users.
  • The mechanisms (molecular, genetic, social) that drive differences in COPD susceptibility and progression in current and former commercial tobacco users.
  • The role of new and emerging tobacco products in the development and exacerbation of asthma, emphysema, COPD, or idiopathic pulmonary fibrosis.
  • Impact of tobacco product use on the general lung health of youth or individuals in other tobacco priority populations.

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