Henry  Lester , Ph.D.

California Institute of Technology
email: lester@caltech.edu
 

Grants

Nicotinic receptors in nicotine addiction 2008 (Cycle XVII)
  17RT-0127 $634,779
Hyperactive nicotine receptors 2003 (Cycle XII)
  12RT-0245 $675,487
Hyperactive nicotine receptors 2000 (Cycle IX)
  9RT-0182 $1,138,225
Hyperactive nicotine receptors 1997 (Cycle VI)
  6RT-0044 $486,158
-Heterologous Expression of Brain Nicotinic Acetylcholine Re 1995 (Cycle IV)
  4RT-0286 $598,774

Periodicals

Enhanced expression of hypersensitive a4 nAChR in adult mice increases the loss of midbrain dopaminergic neurons
  Periodical: FASEB Journal
  Author(s): Schwarz, J., Schwarz S., Dorigo, O., Stutzer, A., Wegner, F., Labarca, C., Deshpande, P.,
  Yr: 2006 Vol: Nbr: 20 Pgs: 935-946
  Associated Grant: Hyperactive nicotine receptors
     
The prototoxin lynx 1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival
  Periodical: Neuron
  Author(s): Miwa, J., Stevens T., King S, Caldarone B., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R.
  Yr: 2006 Vol: Nbr: 51 Pgs: 1-14
  Associated Grant: Hyperactive nicotine receptors
     
An angstrom scale interaction between plasma membrane ATP-gated P2X2 and a4B2 nicotine channels measured with FRET and TIRF microscopy
  Periodical: Journal of Neuroscience
  Author(s): Khakh BS, Fisher JA, Nashmi R, Bowser DN and Lester HA
  Yr: 2005 Vol: 25 Nbr: Pgs: 6911-6920
  Associated Grant: Hyperactive nicotine receptors
     
An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with FRET and TIRF microscopy.
  Periodical: Journal of Neuroscience
  Author(s): Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA
  Yr: 2005 Vol: 25 Nbr: Pgs: 6911 - 6920
  Associated Grant: Hyperactive nicotine receptors
     
Novel seizure phenotyphe and sleep disruptions in Knock-in mice with hypersensitive a4 nicotinic receptors
  Periodical: Journal of Neuroscience
  Author(s): Fonck C, Cohen BN, Nashmi R, Whiteaker P, Wagenaar D, Rodrigues-Pinguet N, Deshpande P,
  Yr: 2005 Vol: Nbr: 25:49 Pgs: 11396-11411
  Associated Grant: Hyperactive nicotine receptors
     
Nicotine action on a4 receptors: sufficient for reward, tolerance and sensitization science
  Periodical: Science
  Author(s): Tapper A, McKinney S, Nashmi R, Schwarz J, Deshapande P, Labarca C, Whiteaker P, Collins
  Yr: 2004 Vol: Nbr: 306 Pgs: 1029-1032
  Associated Grant: Hyperactive nicotine receptors
     
Nicotine action on alpha4* receptors: sufficiennt for reward, tolerance and sensitization.
  Periodical: Science
  Author(s): Tapper A, McKinney S, Nashmi R, Schwarz J, Lester H, et al.
  Yr: 2004 Vol: 306 Nbr: Pgs: 1029 - 1032
  Associated Grant: Hyperactive nicotine receptors
     
Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: Effects of localization, trafficking and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
  Periodical: Journal of Neuroscience
  Author(s): Lester HA, Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE
  Yr: 2003 Vol: 23 Nbr: Pgs: 11554-11567
  Associated Grant: Hyperactive nicotine receptors
     
Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: Effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
  Periodical: Journal of Neuroscience
  Author(s): Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA
  Yr: 2003 Vol: 23 Nbr: Pgs: 11554-11567
  Associated Grant: Hyperactive nicotine receptors
     
Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nivotinic receptors.
  Periodical: Journal of Neuroscience
  Author(s): Fonck C, Nashmi R, Deshpande P, Damaj M, Riedel A, Schwarz J, Collins A, et.al
  Yr: 2003 Vol: 23 Nbr: 7 Pgs: 2582-2590
  Associated Grant: Hyperactive nicotine receptors
     
Alpha4Beta2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response targets for both nicotine and ethanol.
  Periodical: Alcoholism: Clinical and Experimental Research
  Author(s): Owens JC, Balogh SA, McClure-Begley TD, Butt CM, Mabarca C, Lester HA, et.al
  Yr: 2003 Vol: 27 Nbr: Pgs: 1867-75
  Associated Grant: Hyperactive nicotine receptors
     
Point mutant mice with hypersensitive a4 nicotinic receptors show dopaminergic deficits and increased anxiety
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Labarca C, Schwarz J, Deshpande P, et al
  Yr: 2001 Vol: 98 Nbr: Pgs: 2786-2791
  Associated Grant: Hyperactive nicotine receptors
     
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA
  Yr: 1998 Vol: Nbr: Pgs:
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
From ab initio quantum mechanics to molecular neurobiology: A cation- binding site in the nicotinic receptor
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, Dougherty DA
  Yr: 1998 Vol: 95 Nbr: Pgs: 12088-12095
  Associated Grant: Hyperactive nicotine receptors
     
Site-specific, photochemical proteolysis applied to ion channels In Vivo
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): England P, Lester HA, Davidson N, Dougherty DA
  Yr: 1997 Vol: 94 Nbr: Pgs: 11025-11030
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Expression and circular dichroism studies of the extracellular domain of the alpha subunit of the nicotinic acetylcholine receptor
  Periodical: Journal of Biological Chemistry
  Author(s): West AP, Bjorkman PJ, Dougherty DA, Lester HA
  Yr: 1997 Vol: 272 Nbr: Pgs: 25468-25473
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Voltage-jump relaxation kinetics for wild type and chimeric beta subunits of neuronal nicotinic receptors
  Periodical: Journal of General Physiology
  Author(s): Figl A, Labarca C, Davidson N, Lester HA, Cohen BN
  Yr: 1996 Vol: 107 Nbr: 3 Pgs: 369-379
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Interactions of leucine residues at the 9' position of the M2 domain of AChR probed using unnatural mino acid mutagenesis
  Periodical: Biophysics Journal
  Author(s): Kearney P, Zhong C, Nowak W, et al
  Yr: 1996 Vol: 2 Nbr: Pgs: A251
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Nicotinic receptor binding site probed with unnatural amino-acid incorporation in intact cells
  Periodical: Science
  Author(s): Nowak MW, Kearney PC, Sampson JR, et al
  Yr: 1995 Vol: 268 Nbr: 5209 Pgs: 439-442
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic recptors
  Periodical: Nature
  Author(s): Labarca C, Nowak M, Zhang H, Tang L, Deshpande P, Lester HA
  Yr: 1995 Vol: 376 Nbr: 6540 Pgs: 514-516
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Examination of the nicotinic acetylcholine binding site using unnatural amino acid mutagenesis
  Periodical: Biophysical Journal
  Author(s): Nowak MW, Kearney PC, Saks ME, et al
  Yr: 1995 Vol: 2 Nbr: Pgs: A233
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
The apparent affinity of substance P for the neuronal nAChR is not determined by a single domain of the beta-subunit
  Periodical: Biophysical Journal
  Author(s): Stafford GA, Oswald RE, Figl A, Cohen BN, Lester HA, Weiland GA
  Yr: 1994 Vol: 66 Nbr: Pgs: A432
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Novel functional domains of the rat neuronal nicotinic beta subunit
  Periodical: Society for Neuroscience Abstracts
  Author(s): Figl A, Cohen BN, Gollub J, Davidson N, Lester HA
  Yr: 1993 Vol: 19 Nbr: Pgs: 8
  Associated Grant:
     
Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and for alkali metal cations
  Periodical: Journal of General Physiology
  Author(s): Cohen BN, Labarca C, Davidson N, Lester HA
  Yr: 1992 Vol: 100 Nbr: 3 Pgs: 373-400
  Associated Grant:
     
TRIS+ NA+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region
  Periodical: Journal of General Physiology
  Author(s): Cohen BN, Labarca C, Czyzyk L, Davidson N, Lester HA
  Yr: 1992 Vol: 99 Nbr: Pgs: 545-572
  Associated Grant:
     
Subtypes of the beta subunit confer different antagonist sensitivities on neuronal nicotinic receptors
  Periodical: Society for Neuroscience Abstracts
  Author(s): Cohen BN, Figl A, Quick MW, Ishida AT, Lester HA
  Yr: 1992 Vol: 18 Nbr: Pgs: 1508
  Associated Grant:
     
Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission
  Periodical: Molecular Pharmacology
  Author(s): Charnet P, Labarca C, Lester HA
  Yr: 1992 Vol: 41 Nbr: 4 Pgs: 708-717
  Associated Grant:
     
Regions of the beta subunit of the neuronal nicotinic receptor affecting agonist selectivity
  Periodical: Society for Neuroscience Abstracts
  Author(s): Figl A, Cohen BN, Quick MW, Yang X-C, Lester HA
  Yr: 1992 Vol: 18 Nbr: Pgs: 1508
  Associated Grant:
     
Regions of beta4.beta2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors
  Periodical: FEBS Journal
  Author(s): Figl A, Cohen BN, Quick MW, Davidson N, Lester HA
  Yr: 1992 Vol: 308 Nbr: 3 Pgs: 245-248
  Associated Grant:
     
The permeation pathway of neurotransmitter-gated ion channels
  Periodical: Annual Review of Biophysics and Biomolecular Structure
  Author(s): Lester HA
  Yr: 1992 Vol: 21 Nbr: Pgs: 267-292
  Associated Grant:
     
Ion-selectivity of mutated and wild-type nicotinic ACh channels
  Periodical: Biophysics Journal
  Author(s): Cohen BN, Labarca C, Davidson N, Lester H
  Yr: 1991 Vol: 59 Nbr: Pgs:
  Associated Grant:
     
Point mutant mice with hypersensitive alpha4 nicotinic receptors show dopaminergic deficits and increased anxiety
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Labarca C, Schwarz J, Deshpande P, et al
  Yr: 98 Vol: Nbr: Pgs: 2786-2791
  Associated Grant: Hyperactive nicotine receptors
     
Regions of beta-2 and beta-4 responsible for differences between the equilibrium dose-response relationships of the alpha3beta2 and alpha3beta4 neuronal nicotinic receptors
  Periodical: Journal of General Physiology
  Author(s): Cohen BN, Figl A, Quick M, Labarca C, Davidson N, Lester HA
  Yr: 0 Vol: Nbr: Pgs:
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re
     
Regions of beta2 and beta4 responsible for differences between the equilibrium dose-response relatioships of the alpha3beta2 and alpha3beta4 neuronal nicotinic receptors
  Periodical: Journal of General Physiology
  Author(s): Cohen BN, Figl A, Quick MW, Labarca C, Davidson N, Lester HA
  Yr: 0 Vol: Article in Nbr: Press Pgs:
  Associated Grant: -Heterologous Expression of Brain Nicotinic Acetylcholine Re