Michael  Kelner , M.D., M.S.

University of California, San Diego
email: mkelner@ucsd.edu
 

Grants

Studies of novel antitumor agents for lung carcinoma 2000 (Cycle IX)
  9RT-0057 $833,491
Isolation of lung tumor proteins for a novel treatment 1998 (Cycle VII)
  7IT-0001 $75,000
Studies of novel antitumor agents for lung cancers 1998 (Cycle VII)
  7RT-0002 $306,000
Cloning of a Lung Tumor Transport Gene for Drug Development 1995 (Cycle IV)
  4IT-0194 $104,966
SAR Studies of Novel antitumor Agents for Lung Carcinomas 1995 (Cycle IV)
  4RT-0226 $403,338

Periodicals

Reaction of irofulven with zinc and acid
  Periodical: Journal of Natural Products
  Author(s): McMorris TC, Moon S, Kelner MJ
  Yr: 2003 Vol: 66 Nbr: Pgs: 310-312
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Structure-activity relationship studies of illudins: Analogs possessing a spiro-cyclobutane ring.
  Periodical: Journal of Organics Chemistry
  Author(s): McMorris TC, Cong Q, Kelner MJ
  Yr: 2003 Vol: 68 Nbr: Pgs: 9648-9653
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Genotoxic action of anti-tumor illudin compounds including irufulven.
  Periodical: DNA Repair
  Author(s): Jaspers NGJ, Raams A, Kelner MJ, Ng J, Takeda S, McMorris, Hoeijmakers JHJ
  Yr: 2002 Vol: 11 Nbr: Pgs: 1027-1038
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Sesquiterpenes from omphalotus illudens
  Periodical: Phytochemistry
  Author(s): McMorris, Kashinatham A, Lira R, Rundgren H, Gantzel PK, Kelner MJ, Dawes R
  Yr: 2002 Vol: 61 Nbr: Pgs: 395-398
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Enhanced antitumor activity of irofulven in combination with antimitotics.
  Periodical: Investigational New Drugs
  Author(s): Kelner MJ, McMorris TC, Rojas RJ, Trani NA, Estes L
  Yr: 2002 Vol: 20 Nbr: Pgs: 267-279
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C.
  Periodical: Cancer Chemotherapy and Pharmacology
  Author(s): Kelner MJ, McMorris TC, Rojas RJ, Trani NA and Estes I
  Yr: 2002 Vol: 49 Nbr: Pgs: 412-418
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Irofulven is synergistic with multiple chemotherapeutic agents.
  Periodical: American Association for Cancer Research
  Author(s): Kelner MJ, and McMorris TC
  Yr: 2002 Vol: 43 Nbr: 60 Pgs:
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and related analogues.
  Periodical: Journal of Organics Chemistry
  Author(s): McMorris TC, Yu J, Lira R, Dawe R, MacDonald JR, and Kelner MJ
  Yr: 2001 Vol: 6 Nbr: Pgs: 6158 - 6163
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Activity of Irofulven (MGI 114, HMAF) in combination with other chemotherapeutic agents
  Periodical: Proceedings of the American Association for Cancer Research
  Author(s): Kelner MJ, McMorris TC
  Yr: 2001 Vol: 42 Nbr: 476 Pgs: 88
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Phage display panning of irofulven identifies potential intracellular targets.
  Periodical: Proceedings of the American Association for Cancer Research
  Author(s): Kelner MJ, Tsigelny I, Sharikov V, Ten Eyck LF, Elayadi AN, McMorris TC
  Yr: 2001 Vol: Nbr: Pgs: 45
  Associated Grant: Isolation of lung tumor proteins for a novel treatment
     
Phage display panning of irofulven identifies potential intracellular targets
  Periodical: Clinical Cancer Research
  Author(s): Kelner MJ, Tsigelny I, SHarikov V, Ten Eyck LF, Elayadi AN, McMorris TC
  Yr: 2001 Vol: 7 Nbr: Pgs:
  Associated Grant: Isolation of lung tumor proteins for a novel treatment
     
Phage display panning of irofulven identifies potential intracellular targets.
  Periodical: Clinical Cancer Research
  Author(s): Kelner MJ, Tsigelny I, Sharikov V, et al
  Yr: 2001 Vol: 7 Nbr: Pgs:
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Structure-activity studies of antitumor agent irofulven (HMAF) and related analogues.
  Periodical: Journal of Organics Chemistry
  Author(s): McMorris TC, Yu J, Lira R, Dawe R, MacDonald JR, Kelner MJ
  Yr: 2001 Vol: 6 Nbr: Pgs: 6158-6163
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with Topotecan.
  Periodical: Leukemia
  Author(s): Kelner M, McMorris TC, Estes L, Samson KM, Trani NA, MacDonald JR
  Yr: 2000 Vol: 14 Nbr: Pgs: 136-141
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Efficacy of MGIII 114 against the MRP-positive metastatic MV522 lung carcinoma xenograft
  Periodical: Anti-cancer Drugs
  Author(s): Kelner, MJ, McMorris TC, Estes MY, et al
  Yr: 2000 Vol: 11 Nbr: Pgs: 217-224
  Associated Grant: Studies of novel antitumor agents for lung cancers
     
Sequiterpenes from the basidiomycete omphalotus illudens.
  Periodical: Journal of Natural Products
  Author(s): McMorris TC, Lira R, Gantzel PK, Kelner MJ, Dawe R
  Yr: 2000 Vol: 63 Nbr: Pgs: 1557-1559
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Anti-leukemic action of the novel agent MGI 114 HMAF and synergistic action with Topotecan
  Periodical: Leukemia
  Author(s): Kelner MJ, McMorris TC, Estes KM, et al
  Yr: 2000 Vol: 14 Nbr: Pgs: 136-141
  Associated Grant: Studies of novel antitumor agents for lung cancers
     
Identification of proteins binding to acylfulvenes.
  Periodical: Proceedings of the American Association for Cancer Research
  Author(s): Kelner MJ, Elayadi A, McMorris TC
  Yr: 2000 Vol: 41 Nbr: 656 Pgs:
  Associated Grant: Isolation of lung tumor proteins for a novel treatment
     
Efficacy of MGI 114 against the MRP-positive metastatic MV522 lung carcinoma xenograft.
  Periodical: Anti-cancer Drugs
  Author(s): Kelner MJ, McMorris TC, Estes LA, Oval MY, Rojas RJ, Lynn JR, Lanham KA, Samson KM.
  Yr: 2000 Vol: 11 Nbr: Pgs: 217-224
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Preparation and biological activity of amino acid and peptide conjugates of antitumor hyroxylmethylacylfulvene.
  Periodical: Journal of Medicinal Chemistry
  Author(s): McMorris TC, Yu J, Ngo HT, Wang H, Kelner MJ
  Yr: 2000 Vol: 43 Nbr: Pgs: 3577-3580
  Associated Grant: Studies of novel antitumor agents for lung carcinoma
     
Characterization of MGI 114 (HMAF): Histiospecific toxicity in human tumor cell lines
  Periodical: Cancer Chemotherapy and Pharmacology
  Author(s): Kelner MJ, McMorris TC, Montoya MA, et al
  Yr: 1999 Vol: Nbr: Pgs:
  Associated Grant: Studies of novel antitumor agents for lung cancers
     
Metabolism of antitumor MGI 114 (HMAF) rat liver cytosol
  Periodical: Drug Metabolism and Disposition
  Author(s): McMorris TC, Elayadi AN, Yu J, Hu Y, Kelner MJ
  Yr: 1999 Vol: Nbr: Pgs:
  Associated Grant: Studies of novel antitumor agents for lung cancers
     
Metabolism of antitumor Acylfulvene by rat liver cytosol
  Periodical: Biochemical Pharmacology
  Author(s): McMorris TC, Elayadi AN, Yu J, Kelner MJ
  Yr: 1999 Vol: 57 Nbr: Pgs: 83-88
  Associated Grant: Studies of novel antitumor agents for lung cancers
     
Efficacy of MGI 114 against the MRP-positive MV 522 lung carcinoma xenograft
  Periodical: Proceedings of the American Association for Cancer Research
  Author(s): Kelner MJ, McMorris TC, Estes LA, Oval MY, Rojas RJ, Samson KM
  Yr: 1999 Vol: Nbr: 1992 Pgs: 300
  Associated Grant: Studies of novel antitumor agents for lung cancers
     
Efficacy of MGI 114 (6-hydroxymethylfulvene, HMAF)against the mdrI/gp170 Metastatic MV522 lung carcinoma xenograft
  Periodical: European Journal of Cancer
  Author(s): Kelner MJ, McMorris TC, Estes L, et al
  Yr: 1998 Vol: 34 Nbr: Pgs: 908-913
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Characterization of Acylfulvene histiospecific toxicity in human tumor cell lines
  Periodical: Cancer Chemotherapy and Pharmacology
  Author(s): Kelner MJ, McMorris TC, Montoya MA, et al
  Yr: 1998 Vol: 41 Nbr: Pgs: 237-242
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
The design and total synthesis of antitumor Acylfulvenes
  Periodical: Journal of Organics Chemistry
  Author(s): McMorris TC, Yu J, Hi Y, et al
  Yr: 1997 Vol: 62 Nbr: Pgs: 3015-3018
  Associated Grant: Cloning of a Lung Tumor Transport Gene for Drug Development
     
Characterization of cellular accululation and toxicity of Illudin S in sensitive and non-sensitive tumor cells
  Periodical: Cancer Chemotherapy and Pharmacology
  Author(s): Kelner MJ, McMorris TC, Montoya MA, et al
  Yr: 1997 Vol: 40 Nbr: Pgs: 65-71
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols
  Periodical: Tetrahedron Letters
  Author(s): McMorris TC, Yu J, Estes LA, Kelner MJ
  Yr: 1997 Vol: 53 Nbr: Pgs: 14579-14590
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Acylfulvenes, a new class of potent antitumor agents
  Periodical: Experientia
  Author(s): McMorris TC, Kelner MJ, Wang W, Diaz MA, Estes LA, Taetle R
  Yr: 1996 Vol: 52 Nbr: (1) Pgs: 75-80
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Efficacy of HMAF (MGI-114-02) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
  Periodical: Investigational New Drugs
  Author(s): Kelner MJ, McMorris TC, Estes L, et al
  Yr: 1996 Vol: 14 Nbr: Pgs: 161-167
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Hydroxymethylacylfulvene: an Illudin derivative with superior antitumor properties
  Periodical: Journal of Natural Products
  Author(s): McMorris TC, Kelner MJ, Wang W, et al
  Yr: 1996 Vol: 59 Nbr: Pgs: 896-899
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Nonresponsiveness of the metastatic human lung carcinoma MV522 xenograft to conventional anticancer agents
  Periodical: Anticancer Research
  Author(s): Kelner MJ, McMorris TC, Estes L, et al
  Yr: 1995 Vol: 15 Nbr: 3 Pgs: 867-872
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Efficacy of Acylfulvene Illudin analogs against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents retention of activity against various phenotypes.
  Periodical: Cancer Research
  Author(s): Kelner MJ, McMorris TC, Estes L, et al
  Yr: 1995 Vol: 55 Nbr: 21 Pgs: 4936-4940
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
In vitro and in vivo studies on the anticancer activity of dehydroilludin M
  Periodical: Anticancer Research
  Author(s): Kelner MJ, McMorris TC, Taetle R
  Yr: 1995 Vol: 15 Nbr: 3 Pgs: 873-878
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells: unusually high sensitivity of ERCC2 and ERCC3 DNA helicase deficient mutants in comparison to other chemotherapeutic agents
  Periodical: Biochemical Pharmacology
  Author(s): Kelner MJ, McMorris L, Estes M, et al
  Yr: 1994 Vol: 48 Nbr: 2 Pgs: 403-409
  Associated Grant: SAR Studies of Novel antitumor Agents for Lung Carcinomas
     
HPLC analysis of novel anticancer agents - illudins and their analogs
  Periodical: Journal of Liquid Chromatography
  Author(s): Brandsteterova E, Kelner MJ, McMorris TC, Wang W, Bagnell R
  Yr: 1993 Vol: 16 Nbr: 1 Pgs: 115-125
  Associated Grant:
     
Characterization of the energy-dependent illudin transport system in immortal and tumor cells
  Periodical: Toxicologist
  Author(s): Kelner MJ, McMorris TC
  Yr: 1993 Vol: 13 Nbr: Pgs: 315
  Associated Grant:
     
Repair of illudin induced DNA damage requires involvement of ERCC-2 and ERCC-3 DNA repair proteins prior to ERCC-1 action
  Periodical: Toxicologist
  Author(s): McMorris TC, Kelner MJ
  Yr: 1992 Vol: 12 Nbr: Pgs: 155
  Associated Grant:
     
HPLC determination of a new anticancer agent (acylfulvene) in serum
  Periodical: Neoplasma
  Author(s): Brandsteterova E, Kelner MJ, McMorris TC, Estes L, Bagnell R, Montoya M
  Yr: 1992 Vol: 39 Nbr: 6 Pgs: 369-373
  Associated Grant:
     
Preclinical evaluation of illudins as anti-cancer agents: Basis for selective cytotoxicity
  Periodical: Journal of the National Cancer Institute
  Author(s): Kelner MJ, McMorris TC, Taetle R
  Yr: 1990 Vol: 82 Nbr: Pgs: 1562-1565
  Associated Grant: